High doses in medicine

Note that although in general, diagnostic doses are too low to give immediate effects to the tissues and only induce a risk of cancer and genetic defects, this is not always the case. The image below is a result of a series of coronary angioplasties and angiograms (i.e. the diagnostic use of x-rays). These diagnostic procedures obviously induced a serious tissue reaction due to the massive dose delivered that ultimately required a skin graft