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Diagnostic Imaging Pathways - Breast Mass

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Fibroadenoma

Image 1 (Ultrasound): Within the upper outer quadrant of the left breast at the 2 o'clock position is a well circumscribed, ovoid hypoechoic lesion measuring 137mm maximally. No contained calcification or vascularity is identified. The appearance is consistent with, but not diagnostic of, a fibroadenoma.

       
2 Click to view full size image   Fibroadenoma

Image 2 (H&E, x2.5): Histological section of a fibroadenoma showing compressed ducts (intra-canalicular growth pattern) surrounded by mild and bland stromal hypercellularity. The ducts are lined by a dual population of uniform epithelial and myoepithelial cells.

       
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Breast Carcinoma

Image 3a (Mammogram, right breast): A non-calcified 22mm mass is present in the upper inner quadrant of the right breast.

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Image 3b (Ultrasound, right breast): Ultrasound of the same lesion showed an ill-defined solid mass with irregular margins, distortion of adjacent stroma and posterior acoustic shadowing, features which are suspicious for malignancy. Biopsy confirmed an invasive ductal carcinoma.

 
       
4a Click to view full size image   Breast Carcinoma

Image 4a: Mastectomy showing an irregular pale tumour (arrow) with surrounding fibrosis consistent with a breast carcinoma.

4b Click to view full size image   Image 4b (H&E, x2.5): Histological section of a moderately differentiated (Grade 2) invasive ductal carcinoma, type not otherwise specified, infiltrating through the breast parenchyma and surrounded by desmoplastic stroma. Occasional poorly formed tubules can be seen at the periphery (arrows).
       
5 Click to view full size image  

Breast Carcinoma

Image 5 (H&E, x10): Histological section of a typical invasive lobular carcinoma showing the classical alignment of single cells in rows.


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